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Fetal Neurology · Focused Exam

Targeted Scan of the Fetal Brain

A dedicated, in-depth ultrasound exam that allows detailed assessment of the fetal brain's structure, development and anatomical function.

1What Is the Exam 2When It's Performed 3How It's Performed 4When to Consider It 5Frequently Asked Questions
What Is the Exam

When the anatomy scan raises suspicion of an abnormal finding, or when certain risk factors are present, a targeted fetal brain scan can be performed — a dedicated, in-depth ultrasound exam that allows a detailed assessment of the brain's structure, development and anatomical function.

01 Purpose of the Exam

The scan is designed to provide a broad, accurate picture of brain development, and to enable the earliest possible identification of structural abnormalities or signs that may indicate a neurological developmental disorder. In many cases it provides reassuring information and confirms normal brain development, while in others it helps guide informed medical decisions and appropriate further work-up.

02 Importance of the Exam

The exam provides an in-depth assessment of the fetal brain, helps identify conditions that require medical attention at an early stage, and in many cases offers peace of mind and confirmation of normal development. When there is a medical recommendation for the exam, it is advisable to see a specialist gynecologist with dedicated experience in the field, in order to receive the most professional and accurate assessment.

When It's Performed
Timing is individually tailored

The timing is determined according to the reason for referral and the findings identified during pregnancy follow-up, since imaging capabilities vary with gestational week.

At any stage of pregnancy, when an abnormal finding is suspected

In cases where an abnormal finding is suspected, the scan can be performed at any stage of pregnancy, bearing in mind that imaging capabilities and the findings that can be assessed vary with gestational week. In most cases, for optimal assessment of the fetal brain structures, it is recommended to perform the scan in the third trimester, between weeks 30-32, when brain development is more advanced and allows for optimal assessment of the development of brain structures and cortical sulcation.

How It's Performed
By a specialist gynecologist

The exam is performed by a specialist gynecologist with dedicated experience in the field, in most cases combining an abdominal and a transvaginal approach.

01

Combined Approach

The transvaginal probe allows for higher resolution, especially when the fetus is in a cephalic (head-down) position.

02

3D Technologies

When needed, additional imaging angles and precise assessment of structures.

03

Systematic Examination

Skull structure, the ventricular system, midline structures such as the corpus callosum and cavum septum pellucidum, posterior fossa structures, the brainstem, and cortical development according to gestational week.

04

Blood Flow & Measurements

Assessment of cerebral blood flow and additional measurements indicating normal brain development.

When to Consider It
Five Groups of Conditions

There are several medical conditions in which a more in-depth and focused assessment of the fetal brain is recommended, in order to identify abnormal findings and assess their clinical significance.

Findings on a Routine Anatomy Scan
01 Ventriculomegaly

Enlargement of the brain ventricles may indicate an increased accumulation of cerebrospinal fluid or a change in the development of brain structures. In many cases this is a mild finding with no clinical significance, but at times it requires further evaluation and close follow-up. A targeted scan allows assessment of the severity of the enlargement and checks for any additional associated findings.

02 Asymmetry in Brain Structures

When there is a difference in size or structure between the two sides of the brain, a more detailed assessment of the brain anatomy is needed. At times this is a normal developmental variation, but in some cases the asymmetry may indicate a developmental disorder or an injury that occurred during pregnancy.

03 Intracranial Cysts

Cysts within the fetal brain may appear as part of a normal developmental process or be related to various medical conditions such as infections or developmental disorders. A targeted scan allows assessment of their location, size and characteristics, and accordingly provides informed counseling regarding their significance.

04 Midline Structure Disorders

Such as an abnormality or absence of the cavum septum pellucidum or the corpus callosum. Recognizing these disorders and precisely assessing the abnormality, along with associated findings in the brain, is critical for determining the significance and severity of the findings.

05 Posterior Fossa Structural Disorders

There is a wide range of posterior fossa structural disorders, from benign findings with no clinical significance to malformations with significant neurological and developmental implications. Therefore, optimal imaging of the posterior fossa in all its components is of great importance, allowing accurate diagnosis and informed medical counseling for parents.

Head Measurements Inconsistent with Gestational Age
06 Head Circumference Smaller Than Expected

A head circumference smaller than the expected range for gestational age may result from a variety of factors, ranging from normal developmental variation to conditions affecting brain development, including microcephaly. A targeted, comprehensive scan of the fetal brain, taking into account differential diagnoses and associated findings, allows for a more accurate assessment of the finding's significance and contributes to diagnosis and informed medical counseling.

07 Head Circumference Larger Than Expected

A head circumference larger than the expected range for gestational age may reflect normal familial variation, but may also be related to enlargement of the brain ventricles, increased cerebrospinal fluid, or other conditions affecting brain structure. A targeted, comprehensive scan of the fetal brain allows for precise assessment of the brain anatomy, identification of associated findings, and distinction between a normal variant and a clinically significant condition, thereby assisting in diagnosis and informed medical counseling.

Suspected Intrauterine Infection
08 Intrauterine Infections

Intrauterine infections may in certain cases affect the development of the fetal brain and central nervous system. Common causes include CMV infection, toxoplasmosis, the Zika virus and other congenital infections. When exposure or infection during pregnancy is suspected, a targeted, comprehensive scan of the fetal brain is recommended, aiming to identify characteristic findings such as changes in brain structure, developmental disorders or abnormal head growth measurements. This assessment assists in early diagnosis, evaluating the severity of the injury, deciding on further work-up and follow-up, and providing informed medical counseling for parents.

Medical & Family Background
09 Significant Medical or Family Background

When there is a family history of brain malformations, genetic diseases that may affect the central nervous system, or developmental delay and/or neurological diseases among family members, there may be an increased risk of conditions affecting fetal brain development. In these cases, a targeted, detailed scan of the fetal brain allows for meticulous anatomical assessment, helps identify subtle findings, and contributes to risk assessment, planning further evaluation as needed, and providing informed medical and genetic counseling.

Conditions Related to the Pregnancy Itself
10 Intrauterine Growth Restriction

Fetuses experiencing growth restriction may be at increased risk for conditions that also affect brain development. A focused exam allows assessment of brain structures and cerebral blood flow, as part of the overall assessment of fetal well-being.

11 Spinal Malformations

Assessment of the spine is an integral part of the fetal brain scan, since there is a heterogeneous group of congenital malformations, including spina bifida and other neural tube defects. Identifying the finding, determining the type and location of the defect, and assessing associated findings require in-depth familiarity with the various types of malformations and their clinical significance. Accurate assessment allows for correct diagnosis, prognosis evaluation, and precise medical counseling.

12 Exposure to Certain Medications

Exposure during pregnancy to medications with the potential to affect fetal development, particularly the central nervous system, may be an indication for a targeted fetal brain scan. The risk depends on the type of medication, the dosage, the duration of exposure, and the stage of pregnancy in which it occurred.
The purpose of the scan is to comprehensively assess the development of brain structures, identify abnormal anatomical findings or signs of impaired nervous system development, and confirm that brain development is consistent with gestational age. The findings assist in risk assessment and in deciding whether further evaluation or dedicated follow-up is needed.

13 Abnormal Findings in Genetic Tests or Fetal MRI

When genetic tests or other imaging exams raise a finding that requires further evaluation, a targeted brain scan serves as an important complementary tool. It allows real-time examination of the brain anatomy and integration of all the data.

Frequently Asked Questions
Why is it important for the exam to be performed by a specialist physician in the field?

Assessing the fetal brain requires a high level of skill, extensive experience and in-depth familiarity with the normal stages of nervous system development throughout pregnancy. This is a unique field combining advanced knowledge in obstetric ultrasound, fetal neurology and fetal imaging. Accurate interpretation of the findings makes it possible to distinguish between normal variations and signs requiring further evaluation, and to provide parents with reliable, well-founded information for decision-making.

Does a targeted brain scan replace fetal brain MRI?

No. A targeted fetal brain scan and diagnosis via fetal brain MRI are complementary tools, each with its own advantages and limitations.

A targeted fetal brain scan is the most detailed ultrasound exam for assessing the anatomy of the brain and central nervous system. It allows dynamic examination of brain structures, blood vessels, the spine and associated findings, while integrating the information with the rest of the pregnancy findings. In many cases, a quality scan performed by a specialist provides all the necessary information, and MRI is not required.

Fetal brain MRI may be needed when there are findings that are not unequivocal on ultrasound, when further assessment of the cortex, white matter or structures difficult to visualize on ultrasound is required, or when complex central nervous system malformations are suspected. In these cases, MRI serves as a complementary exam, not a replacement for the ultrasound scan.

The decision on whether an MRI is needed is made according to the scan findings, gestational age and the clinical question, with the goal of providing the most accurate assessment of the fetal brain.

How long does the exam take?

The duration of the exam varies according to the findings and the stage of pregnancy, and it is usually longer than a routine scan.

Does the exam carry any risk?

This is a standard ultrasound exam, with no radiation, that carries no risk.

Still have questions?

Feel free to reach out for more information or to check suitability for the exam.

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